Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico

  • Yurika Sastyarina
  • Zuhrotun Nafisah
  • Muhammad Yusuf
  • Martalena Ramli
  • Abdul Mutalib
  • Ukun Soedjanaatmadja
Keywords: Dendrimer, PAMAM, nanoparticle, in silico


Dendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used as a template in the preparation of gold nanoparticles. This research was studied the streched cavities of (Poly)amidoamine (PAMAM) dendrimer generation 4 using in silico method. Structure of (Poly) amidoamine (PAMAM) dendrimers generation 4 downloaded from Building Toolkit (DBT) Library and before the simulation structure was prepared. Then molecular dynamics simulations run using the AMBER program at 37°C in aqueous conditions. From analysis, obtained that the furthest distance of streched cavities at the closest distance from the core, region between residues 2 and 3 is 23.696 Å and at the terminal region between residues 100 and 122 is 58.045 Å


Download data is not yet available.


1.Mohanraj, V.J. & Chen, Y., 2006. Nanoparticle. A review Tropical Journal of Pharmaceutical Research 5 (1) : 561-573
2.Tomalia D.A., Baker, H., Dewald, J., Hall, M., Kallos, G., Martin S., Roeck, J., Ryder, J. & Smith P. A., 1985. New Class of Polymers - Starburst-Dendritic Macromolecules. Polymer Journal 17:117–132.
3.Chan, H.K., & Kwok, P.C.L., 2001. Production Methods For Nanodrug Particles Using The Bottom Up Approach. Advance Drug Delivery Reviews 63:406-416.
4.Dietrich, S., Schulze, S., Hietschold, M., & Lang, H., 2011. Au Nanoparticles Stabilised by PEGylated Low Generation PAMAM Dendrimers:Design, Characterisation and Properties. Journal of Colloid and Interface Science
5.Caminade, Anne-marie, Turrin, C.O., Laurent, R., & Ouali, A., Delavaux-nicot, B., 2011. Dendrimers Towards Catalytic, Material, adn
Biomedical Uses. United Kingdom : John Wiley & Sons, Ltd.
6.Esfand, R., & Tomalia, D.A., 2001. Poly(amidoamine) (PAMAM)
Dendrimers from Biomimicry to Drug Delivery and Biomedical Application. Drug Discovery Today 6: 427-436.
7.Maiti, P. K., Cagin, T., Wang, G.F., & Goddard, W.A., 2005. AStructure of PAMAM Dendrimers: Generation 1 Through 11. Macromolecules, 37:6236-6254.
8.Mandal, T., Dasgupta, C., & Maiti, P.K., 2013. Engineering Gold
Nanoparticle Interaction by PAMAM Dendrimer. The Journal Physical Chemistry.
9.Anonim, 2013. Dendrimer library https://sites.google.com/site/dendrimerlibrary/home diakses 3 april 2015
10.Maingi, V., Jain, V., Bharatam, P.V., & Maiti, P.K., 2012. Dendrimer Building Toolkit: Model Building and Characterization of Various Dendrimer Architectures J. Comput. Chem.33, 1997-2011
11.Nurbaiti, S., 2009. Stabilitas Termal dan Pergerakan Dinamis Klenow-Like DNA Polimerase I ITB-1 Berdasarkan Simulasi Dinamika Molekul. Disertasi. Program Studi Kimia Institut Teknologi Bandung
How to Cite
Sastyarina, Y., Nafisah, Z., Yusuf, M., Ramli, M., Mutalib, A., & Soedjanaatmadja, U. (2017). Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico. Journal of Tropical Pharmacy and Chemistry, 4(1), 35-42. https://doi.org/10.25026/jtpc.v4i1.130

Most read articles by the same author(s)