Synthesis and Characterization of Methyl Amino Polystyrene as Resin Material of Chromatography

  • Herman Herman Laboratorium Penelitian dan Pengembangan Kefarmasian FARMAKA TROPIS, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
  • Anni Anggraeni Chemical Analysis and Separation Laboratory, Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor, West Java, 45363 Indonesia
  • Abdul Mutalib Biomolecular Laboratory, Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Singaperbangsa, Bandung, West Java, 40132 Indonesia
  • Husein H. Bahti Chemical Analysis and Separation Laboratory, Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor, West Java, 45363 Indonesia
Keywords: Cation-Exchange Resin, Methylamino Polystyrene

Abstract

Ion-exchange chromatography has been widely used in various separation process and purification. Commercial ion-exchange resin mostly uses polystyrene as stationer phase. This study reviewed the synthesis of cation-exchange resin with polystyrene as starting material. Polystyrene must be activated in order to make one of aromatic carbon chains being able to be binding with acetamide n-hidroxymethyl electrophilic. Polystyrene activation was conducted through two stages, i.e. (1) the formation of amidomethyl polystyrene (AMDP), and followed with (2) elimination of acyl group. The activation of polystyrene generated white methylamino polystyrene (MAP) resin, of which its characterization used spectrophotometry UV, Fourier Transform-Infrared (FTIR), and density of MAP resin confirmed by pycnometer. The results showed that the characterization of FTIR and spectrophotometer UV for AMP exhibited forming amino propyl group at 3374.52 cm-1 with λmax 230 nm due to N–H bond; and the average of density of AMP resin sample was 1.7158 g/mL.

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Published
2019-01-18
How to Cite
Herman, H., Anggraeni, A., Mutalib, A., & Bahti, H. H. (2019). Synthesis and Characterization of Methyl Amino Polystyrene as Resin Material of Chromatography. Journal of Tropical Pharmacy and Chemistry, 4(4), 194-201. https://doi.org/10.25026/jtpc.v4i4.204