Formulation and Characterization on Self Nanoemulsifying Drug Delivery System of Eleutherine Palmifolia Extract Employing Short, Medium, and Long Chain Triglyceride

  • Rahmi Annisa Department of Pharmacy, Faculty of Medical and Health Science, State Islamic University of Maulana Malik Ibrahim, Malang, East Java, Indonesian 65144
  • Yen Yen Ari Indrawijaya Department of Pharmacy, Faculty of Medical and Health Science, State Islamic University of Maulana Malik Ibrahim, Malang, East Java, Indonesian 65144
  • Dewi Sinta Megawati Department of Pharmacy, Faculty of Medical and Health Science, State Islamic University of Maulana Malik Ibrahim, Malang, East Java, Indonesian 65144
  • Ana Fikrotus Zakia Department of Pharmacy, Faculty of Medical and Health Science, State Islamic University of Maulana Malik Ibrahim, Malang, East Java, Indonesian 65144

Abstract

Eleutherine palmifolia (E. palmifolia) is a common plant used as an anticancer drug in Kalimantan, Indonesia. The active compound present in it is naphthoquinone, which has low water solubility and needs to be formulated into SNEDDS preparations to improve its dissolution and bioavailability in the body. The dispersion method is used in the preparation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) and PEG 400 cosurfactants. Furthermore, this study aims to ascertain the effects of oil on the SNEDDS preparations. The results showed that the effect of the preparations on olive oil, VCO, and oleic acid in the organoleptic test produced dark red, clear, and non functional emulsion. The average particle sizes obtained in the AGF media were 61,10, 774,33, and 211,70 nm; in AIF media it amounted to 211,70, 123,65, and 830,22 nm. The pH value for each formula was 6,8, while the average emulsification time for the AGF media was 24,10, 22,53, and 25,75 seconds, and, lastly, for the AIF media, they were 20,96, 19,62, and 23,74 second.

Downloads

Download data is not yet available.
Published
2020-06-22
How to Cite
Annisa, R., Indrawijaya, Y. Y. A., Megawati, D. S., & Zakia, A. F. (2020). Formulation and Characterization on Self Nanoemulsifying Drug Delivery System of Eleutherine Palmifolia Extract Employing Short, Medium, and Long Chain Triglyceride. Journal of Tropical Pharmacy and Chemistry, 5(2), 80-85. https://doi.org/10.25026/jtpc.v5i2.232