Isolation of Caffeine from Carbonated Beverages

  • Amir Hassan Govt.Post Graduate College 23200 Mardan KP
  • Muhammad Ashfaq Department of Organic Chemistry, Govt. Post Graduate College Mardan (2300) Khyber Pakhtunkhwa Pakistan.
  • Ali Khan Department of Organic Chemistry, Govt. Post Graduate College Mardan (2300) Khyber Pakhtunkhwa Pakistan.
  • Muhammad Shakeel Khan Department of Organic Chemistry, Govt. Post Graduate College Mardan (2300) Khyber Pakhtunkhwa Pakistan.
Keywords: Caffeine, liquid-liquid extraction, carbonated beverages, Crystals, Chloroform

Abstract

The work presented on the isolation of naturally occurring alkaloid from carbonated beverages. The extensive presence of caffeine in different plants plays an important role in the long-standing acceptance of caffeine-containing products. Caffeine (3,7-dihydro-1, 3,7-trimethyl-1H-purine-2,6-dione or 1,3,7-trimethylxanthine) is an alkaloid belongs to Methylxanthine family. Liquid-liquid extraction methods were used in the assay of research work. Chloroform was taken as extracting solvent. Solid residue of caffeine was recrystallized from 95% ethanol using 5ml/gram (5ml per gram). It is declared to raise caffeine, effects a number of different drugs include Paracetamol, Benzodiazepines and Aspirin and amount of plasma free Fatty acids increases. While inform that in regular sleeping interaction caffeine take place and raise the absorption of certain drugs. Changes in drug metabolizing enzymes, acts as an agent in a microsomal system of the body. The highest amount of caffeine dry crystal is extracted in sting sample while the 7up sample is free from caffeine.

Downloads

Download data is not yet available.

References

[1] M. M. Ali, M. Eisa, M. I. Taha, B. A. Zakaria, and A. A. Elbashir, "Determination of caffeine in some Sudanese beverages by High Performance Liquid Chromatography," Pakistan Journal of Nutrition, vol. 11, p. 336, 2012.
[2] K. Shrivas and H.-F. Wu, "Rapid determination of caffeine in one drop of beverages and foods using drop-to-drop solvent microextraction with gas chromatography/mass spectrometry," Journal of Chromatography A, vol. 1170, pp. 9-14, 2007.
[3] K. H. Chou and L. Bell, "Caffeine Content of Prepackaged National‐Brand and Private‐Label Carbonated Beverages," Journal of food science, vol. 72, 2007.
[4] E. Villarreal, "Energy Drinks And Caffeine: The Science Behind The Billion-Dollar Industry," University of Mississippi, 2014.
[5] R. R. McCusker, B. A. Goldberger, and E. J. Cone, "Caffeine content of energy drinks, carbonated sodas, and other beverages," Journal of Analytical Toxicology, vol. 30, pp. 112-114, 2006.
[6] G. Galasko, K. Furman, and E. Alberts, "The caffeine contents of non-alcoholic beverages," Food and Chemical Toxicology, vol. 27, pp. 49-51, 1989.
[7] A. Mumin, K. F. Akhter, Z. Abedin, and Z. Hossain, "Determination and characterization of caffeine in tea, coffee and soft drinks by solid phase extraction and high performance liquid chromatography (SPE–HPLC)," Malaysian Journal of Chemistry, vol. 8, pp. 045-051, 2006.
[8] K. I. Kwon, D. W. Bourne, and P. C. Ho, "Effect of caffeine on the plasma protein binding and the disposition of ceftriaxone," Journal of pharmacy and pharmacology, vol. 37, pp. 836-839, 1985.
[9] C. Mitoma, T. J. Sorich, and S. E. Neubauer, "The effect of caffeine on drug metabolism," Life sciences, vol. 7, pp. 145-151, 1968.
[10] R. Finn and H. N. Cohen, "Food allergy: fact or fiction," Lancet, vol. 1, pp. 426-428, 1978.
[11] A. Liguori, J. R. Hughes, and J. A. Grass, "Absorption and subjective effects of caffeine from coffee, cola and capsules," Pharmacology Biochemistry and Behavior, vol. 58, pp. 721-726, 1997.
[12] A. Nehlig, J.-L. Daval, and G. Debry, "Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects," Brain Research Reviews, vol. 17, pp. 139-170, 1992.
[13] J. A. Nathanson, "Caffeine and related methylxanthines: possible naturally occurring pesticides," Science, vol. 226, pp. 184-187, 1984.
[14] A. Darragh, R. Lambe, D. Hallinan, and D. O'Kelly, "Caffeine in soft drinks," The Lancet, vol. 313, p. 1196, 1979.
[15] J. A. Carrillo and J. Benitez, "Clinically significant pharmacokinetic interactions between dietary caffeine and medications," Clinical pharmacokinetics, vol. 39, pp. 127-153, 2000.
[16] E. Childs and H. de Wit, "Enhanced mood and psychomotor performance by a caffeine-containing energy capsule in fatigued individuals," Experimental and clinical psychopharmacology, vol. 16, p. 13, 2008.
[17] C. Alford, H. Cox, and R. Wescott, "The effects of red bull energy drink on human performance and mood," Amino acids, vol. 21, pp. 139-150, 2001.
[18] A. Astrup, S. Toubro, S. Cannon, P. Hein, L. Breum, and J. Madsen, "Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers," The American journal of clinical nutrition, vol. 51, pp. 759-767, 1990.
[19] H. D. Vlajinac, R. R. Petrović, J. M. Marinković, S. B. Šipetić, and B. J. Adanja, "Effect of caffeine intake during pregnancy on birth weight," American journal of epidemiology, vol. 145, pp. 335-338, 1997.
Published
2020-06-30
How to Cite
Hassan, A., Ashfaq, M., Khan, A., & Khan, M. S. (2020). Isolation of Caffeine from Carbonated Beverages. Journal of Tropical Pharmacy and Chemistry, 5(1), 33-38. https://doi.org/10.25026/jtpc.v5i1.234