Imunomodulator Activity of Three Types “Kayu Kuning” Borneo

Authors

  • Dwi Hadi Setya Palupi
  • Riski Sulistiarini PHAMACOLOGY & PHARMACOGNOCY https://orcid.org/0000-0003-4806-9763
  • Vita Olivia Siregar Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

DOI:

https://doi.org/10.25026/jtpc.v6i1.375

Keywords:

Immunomodulator, Arcangelisia Flava, Fibraurea tinctoria, Coscinium fensteratum

Abstract

The immune system is a system that plays a role in maintaining the integrity of the body against the dangers that various foreign objects can cause. Immunomodulators are substances or substances that can change/modify the immune system. Empirically, Kayu Kuning or Yellow Wood is used as a cleaner for post-partum conditions. Yellow wood in East Kalimantan is the name for three species, namely Arcangelisia Flava, Fibraurea tinctoria, and Coscinium fensteratum. With the approach of improving the immune system and metabolism, immunomodulatory tests carried out on three types of yellow wood found in Borneo Island. The immunomodulatory activity of Yellow wood  steam extract in the non-specific immune response test used phagocytic index and organ index parameters where BALB/c female mice were randomly divided into 16 treatment groups which included a normal group, an immunostimulant comparison group (Levamisole 2.5 mg/kg body weight), an immunosuppressant comparison group (Methylprednisolone 40mg/kg BW), a test extract group with a dose of 100 mg/kg body weight, for the ethanolic extracts of A. Flava, F. tinctoria and C. fenestratum, respectively. Based on the study results, it means that the methanol extract of A. Flava methanol extract had immunostimulating activity, while the methanol extract of F. tinctoria and C. fenestratum showed an immunosuppressant effect

Downloads

Download data is not yet available.

References

[1] L. B. Nicholson, ‘The immune system’, Essays Biochem., vol. 60, no. 3, pp. 275–301, Oct. 2016, doi: 10.1042/EBC20160017.
[2] J. S. Marshall, R. Warrington, W. Watson, and H. L. Kim, ‘An introduction to immunology and immunopathology’, Allergy Asthma Clin. Immunol. Off. J. Can. Soc. Allergy Clin. Immunol., vol. 14, no. Suppl 2, pp. 49–49, Sep. 2018, doi: 10.1186/s13223-018-0278-1.
[3] M. Schwartz and I. R. Cohen, ‘Autoimmunity can benefit self-maintenance’, Immunol. Today, vol. 21, no. 6, pp. 265–268, Jun. 2000, doi: 10.1016/S0167-5699(00)01633-9.
[4] M. Al-Hariri, ‘Immune’s-boosting agent: Immunomodulation potentials of propolis’, J. Fam. Community Med., vol. 26, no. 1, pp. 57–60, 2019, doi: 10.4103/jfcm.JFCM_46_18.
[5] National Cancer Institute, ‘Immunostimulant’, Dictionary of Cancer Term. National Cancer Institute at the National Institutes of Health, USA.
[6] Zara Risoldi Cochrane, ‘About Immunosuppressant Drugs’, Healthline Media, USA, 2019.
[7] R. Sulistiarini, A. A. Soemardji, Elfahmi, and M. I. Iwo, ‘Pharmacological Activities of Three Kinds “Kayu kuning”: Arcangelisia flava, Fibraurea tinctoria, and Coscinium fenestratum – an Short Review’, J. Trop. Pharm. Chem., vol. 5, no. 2, pp. 150–156, 2020.
[8] Tantri A. Sujono, Ika. T. Harya. Kusumowati, and Rima Munawaroh, "Immunomodulatory activity of muntingia calabura l. Fruits using carbon clearance assay and their total flavonoid and phenolic contents’, Asian J. Pharm. Clin. Res., vol. 13, no. 2, 202AD.
[9] M. I. Iwo, A. A. Soemardji, D. S. Retnoningrum, Sukrasno, and UMU, ‘Immunostimulating effect of pule (Alstonia scholaris L. R.Br., Apocynaceae) bark extracts’, Clin Hemorheol Microcirc, vol. 23, no. 2–4, pp. 177–183, 2000.
[10] P. Shrestha and M. Handral, ‘Evaluation Of Immunomodulatory Activity Of Extract From Rind Of Nephelium Lappaceum Fruit’, Int. J. Pharm. Pharm. Sci., vol. 9, no. 1, 2017, doi: https://doi.org/10.22159/ijpps.2017v9i1.13038.
[11] M.-W. Liu, M.-X. Su, W. Zhang, L.-M. Zhang, Y.-H. Wang, and C.-Y. Qian, ‘Rhodiola rosea suppresses thymus T-lymphocyte apoptosis by downregulating tumor necrosis factor-?-induced protein 8-like-2 in septic rats’, Int. J. Mol. Med., vol. 36, no. 2, pp. 386–398, Aug. 2015, doi: 10.3892/ijmm.2015.2241.
[12] V. M. A. Carneiro, a. C. B. Bezerra, M. Do C. M. Guimarães, and M. I. Muniz-junqueira, ‘Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease’, J. Appl. Oral Sci., vol. 20, no. 5, pp. 203–209, 2012, doi: 10.1590/S1678-77572012000500002.
[13] E. Sasmito, S. Mulyaningsih, and E. Kartika, ‘Aktivitas imunostimulan susu kedelai terhadap imunoglobulin ( IgG , IgA ) dan proliferasi sel limfosit pada mencit Balb / c yang diinduksi hepatitis A Immunostimulant activity of soybean milk against’, Maj. Farm. Indones., vol. 17, no. 3, pp. 156–161, 2006.
[14] B. G. Katzung, Farmakologi dasar dan klinik. 10th ed. Jakarta. EGC. p479 – 489, 10th ed. EGC, 2009.
[15] Wagner, H, Hostettman, and Lea, P.J, Immunostimulants from Higher Plants (recent advances), in Biological active natural products. United Kingdom: Oxford University Press, 1986.
[16] V. Bronte and M. J. Pittet, ‘NIH Public Access’, Natl. Intitutes Health, vol. 39, no. 5, pp. 806–818, 2013, doi: 10.1007/s10439-011-0452-9.Engineering.

Downloads

Published

2022-06-30

How to Cite

Palupi, D. H. S., Sulistiarini, R., & Siregar, V. O. (2022). Imunomodulator Activity of Three Types “Kayu Kuning” Borneo. Journal of Tropical Pharmacy and Chemistry, 6(1), 71–75. https://doi.org/10.25026/jtpc.v6i1.375

Most read articles by the same author(s)