Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method

  • Dwi Saryanti Departemen Teknologi Farmasi Program Studi DIII Farmasi Stikes Nasional
  • Dian Nugraheni Departemen Farmasi Komunitas, Program Studi DIII Farmasi Stikes Nasional
  • Nisa Sindi Astuti Departemen Mikrobiologi Program Studi DIII Farmasi Stikes Nasional
Keywords: Nanoparticles, Betel Leaf Extract, Ionic Gelation, PSA, SEM

Abstract

Nanoparticles are used in drug delivery which can increase mass transfer so increase the absorption and effectiveness of the drug. Therefore, its prospect to improve antibacterial and antioxidants activities of betel leaves. The research aimed to preparation and characterization of betel leaf extract using ionic gelation technique. The formulation of nanoparticles from betel leaf extract with ionic gelation method using alginate and CaCl2 with a ratio of 2.5: 1. The characterization of the nanoparticles includes particle size analysis, zeta potential, particle morphology and determination of flavonoid content. Particle size analysis demonstrated that the betel leaf extract nanoparticles had a particle size of 243,03 ± 1,48 nm, zeta potential of -23,0 ± 0,35 mV and morphology of particle showed that a flat shape. The betle leaf exctract nanoparticle positively contained flavonoid with Rf 0.7 equivalent to quercetin. The betel leaf extract can be made nanoparticles with ionic gelation method using alginate and CaCl2.

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Published
2020-06-30
How to Cite
Dwi Saryanti, Dian Nugraheni, & Nisa Sindi Astuti. (2020). Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method. Journal of Tropical Pharmacy and Chemistry, 5(1), 15-20. https://doi.org/10.25026/jtpc.v5i1.224