Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method
DOI:
https://doi.org/10.25026/jtpc.v5i1.224Keywords:
Nanoparticles, Betel Leaf Extract, Ionic Gelation, PSA, SEMAbstract
Nanoparticles are used in drug delivery which can increase mass transfer so increase the absorption and effectiveness of the drug. Therefore, its prospect to improve antibacterial and antioxidants activities of betel leaves. The research aimed to preparation and characterization of betel leaf extract using ionic gelation technique. The formulation of nanoparticles from betel leaf extract with ionic gelation method using alginate and CaCl2 with a ratio of 2.5: 1. The characterization of the nanoparticles includes particle size analysis, zeta potential, particle morphology and determination of flavonoid content. Particle size analysis demonstrated that the betel leaf extract nanoparticles had a particle size of 243,03 ± 1,48 nm, zeta potential of -23,0 ± 0,35 mV and morphology of particle showed that a flat shape. The betle leaf exctract nanoparticle positively contained flavonoid with Rf 0.7 equivalent to quercetin. The betel leaf extract can be made nanoparticles with ionic gelation method using alginate and CaCl2.Downloads
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References
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[2] Hermawan, A., Eliyani, H., Tyasningsih, W., 2007, Pengaruh Ekstrak Daun Sirih (Piper betle Linn) Terhadap Pertumbuhan Staphylococcus aureus dan Eschericia coli Dengan Metode Difusi Disk, Artikel Ilmiah, Fakultas Kedokteran, Universitas Airlangga, Surabaya
[3] Mufrod, Suwaldi, Wahyuono, S., 2016, Patch Ekstrak Daun Sirih (Piper betle Linn): Pengaruh Penambahan Release Enhancer Substances Terhadap Sifat Fisikokimia dan Aktivitas Antibakteri, Majalah Farmaseutik, Vol 12, No 2
[4] Putri, Z.F., 2010. Uji Aktivitas Antibakteri Ekstrak Etanol Daun Sirih (Piper betle L.) Terhadap Propionibacterium acne Dan Staphylococcus aureus Multiresisten, Skripsi (S1), Universitas Muhammadiyah Surakarta
[5] Andarwulan, N., Wijaya, C.H., Cahyono, D.T., 1996. Aktivitas antioksidan dari daun sirih (Piper betle L.)
[6] Parwata, I., Rita, W.S., Yoga, R., 2009. Isolasi dan uji antiradikal bebas minyak atsiri pada daun sirih (Piper betle Linn) secara spektroskopi ultra violet-tampak. J. Kim. 3, 7–13
[7] Debnath, P., Mondal, A., Hajra, A., Das, C., Mondal, N.K., 2018, Cytogenetic Effects of Silver and Gold Nanoparticles on Allium cepa roots, Journal of Genetic Engineering and Biotechnology
[8] Amani, P., Amani, M., Ahmadi, G., Mahian, O., Wongwises, S., 2018. A critical review on the use of nanoparticles in liquid–liquid extraction. Chem. Eng. Sci. 183, 148–176. https://doi.org/10.1016/j.ces.2018.03.001
[9] Biao, L., Tan, S., Zhang, X., Gao, J., Liu, Z., Fu, Y., 2018. Synthesis and characterization of proanthocyanidins-functionalized Ag nanoparticles. Colloids Surf. B Biointerfaces 169, 438–443
[10] Goyal, et al, 2011, Potential of Novel Drug Delivery Systems for Herbal Drugs, Indian Journal of Pharmaceutical Education and Research, 45 (3), 225-235
[11] Saraei, et al, 2013, Design and Evaluate Alginate Nanoparticles as a Protein Delivery System, Archives of Razi Institute, 68 (2), 139-146
[12] Putri, G.M., dan Atun, S., 2017, Pembuatan dan Karakteristik Nanopartikel Ekstrak Etanol Temu Kunci (Boesenbergia pandurata) Pada Berbagai Variasi Komposisi Alginat, Jurnal Kimia Dasar, Vol 5, No 1
[13] Sidqi, T., 2011, Pembuatan dan Karakterisasi Nanopartikel Ekstrak Temulawak Dengan Metode Ultrasonikasi, Skripsi, Departemen Biokimia Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor
[14] Khakim, A.N., dan Atun, S., 2017, Pembuatan Nanopartikel Ekstrak Kunci Pepet (Kaempferia rotunda) Dengan Alginat Pada Berbagai Variasi Konsentrasi Ion Kalsium, Jurnal Kimia Dasar, Vol 6, No 1
[15] Umawiranda, P.S., dan Cahyaningrum, S.E., 2014, Enkapsulasi Pirazinamid Menggunakan Alginat dan Kitosan. Journal of Chemistry, Volume 3 No 3
[16] George, M., and Abraham, E., 2006, Polyionic Hydrocolloids for the Intestinal Delivery of Protein Drugs: Alginat and Chitosan – a Review, Journal of Controlled Release, 114(1), 1-14
[17] Rowe, R.C., Sheskey, P.J., dan Quinn, M.E., 2009. Handbook Of Pharmaceutical Exipients, 6th ed. Pharmaceutical Press and American Pharmacists Association, London,UK.
[18] Mohanraj, V.J., and Y.Chen., 2006, Nanoparticles: A Review, Tropical Journal of Pharmaceutical Research, Vol. 5 No 1
[19] Abdassah, M., 2017, Nanopartikel Dengan Gelasi Ionik, Farmaka, Volume 15 No 1, 45-52
[20] Martien, R., Adhyatmika, Irianto, I.D.K., Farida, V., Sari, D.P., (2012), Perkembangan Teknologi Nanopartikel Sebagai Sistem Penghantaran Obat, Majalah Farmaseutika, Volume 8, No 1.
[21] Murdock, et al, 2008, Characterization of Nanomaterial Dispersion in Solution Prior to In Vitro Exposure Using Dynamix Light Scattering Technique, Toxicological Sciences, 101 (2), 239-253
[22] Avachat, A.M. dan Patel, V.G., 2014. Self nanoemulsifying drug delivery system of stabilized ellagic acid–phospholipid complex with improved dissolution and permeability. Saudi Pharmaceutical Journal
[23] Poole CRJr and Owens FJ., 2003, Introduction to Nanotechnology, New Jersey: John Wiley & Sons Inc.
[24] Pertiwi, R.D., Yari, C.E., Putra, N. F. 2017. Uji Aktivitas Antioksidan Ekstrak Etanol Limbah Kulit Buah Apel (Malus domestica Borkh) Terhadap Radikal Bebas DPPH (2,2-Diphenyl -1- Picrylhydrazil). Jurnal Ilmiah Manuntung, 2, Akademi Farmasi Samarinda. Samarinda
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Published
2020-06-30
How to Cite
Dwi Saryanti, Dian Nugraheni, & Nisa Sindi Astuti. (2020). Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method. Journal of Tropical Pharmacy and Chemistry, 5(1), 15–20. https://doi.org/10.25026/jtpc.v5i1.224
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